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The concept of the production rate of a steroid hormone was introduced to describe the rate at which the hormone enters the circulation de novo , regardless of its origin, to its effect on the body. This concept is an essential concept in the study of steroid hormones. Its significance is obvious when taking into account the fact that most steroid drugs have their own specific steroid hormone content. The term "progestive" refers only to the time required for the substance to reach its physiological role that is needed for fertility in animals. In the same way, the development of a steroid hormone is a very slow process and can take decades after it is created. For most substances this development is in the range of several years. To put this concept in a scientific context, it is not difficult to see that the rate at which a steroid hormone reaches the circulation varies enormously with its origin/source and its other properties. Even the steroid hormone itself might vary substantially in its ability of reaching its full potential or even in its duration of action. Prostatism The production rate of any hormone is a complex measure and must be measured on the basis of its composition and activity. The importance of the concept is not simply that it can enable us to make an accurate assessment of drug pharmacokinetics. It is also important for assessing the risk of adverse effects of drugs. Hormonal factors The production of anabolic steroids is influenced by many factors including the type of the substance (from the hormone-producing cells to the endocrine glands) and the biological activity of the substance. The production of anabolic androgenic steroids depend upon how effectively the steroids are metabolized , the number of the steroid hormones produced , the activity of the hormone glands and the level of the steroid-like compound, 17-β-estradiol, the endocrine system's reaction to anabolic compounds. Therefore, a high rate of synthesis and metabolism of steroids is only possible if the steroid hormone is also metabolized. This in turn must be controlled because under the right conditions, steroids will accumulate and cause adverse effects. One reason for the low production rate of anabolic steroids in humans is that in humans, the endocrine system has a complex action for the production and secretion of anabolic hormones, such as testosterone. The hormone-probe is not a simple function of metabolism for testosterone but rather involves two additional mechanisms. The interaction between the cell membrane of the endocrine gland with the target cells is mediated by the action of the steroid hormone itself. Also, some steroids interact with specific proteins on the target cell surface, i.e. they affect cell membrane binding properties of the steroid hormone. Thus, Related Article:

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